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aches caused by CSF leak but with normal CSF pressures Neurology 51:786, 1998 MOKRI B, PARISI JE, SCHEITHAUER BW, et al: Meningeal biopsy in intracranial hypotension: Meningeal enhancement on MRI Neurology 45: 1801, 1995 PANULLO SC, REICH JB, KROL G, et al: MRI changes in intracranial hypotension Neurology 43:919, 1993 PAPPENHEIMER JR, HEISEY SR, JORDAN EF, DOWNER J: Perfusion of the cerebral ventricular system in unanesthetized goats Am J Physiol 203:763, 1962 PLEASURE SJH, ABOSCH A, FRIEDMAN, et al: Spontaneous intracranial hypotension resulting in stupor caused by diencephalic compression Neurology 50:1854, 1998 QUINCKE H: Die Lumbarpunktion des Hydrocephalus Klin Wochenschr 28:929, 965, 1891 RADHAKRISHNAN K, AHLSKOG JE, Garrity JA, Kurland LT: Idiopathic intracranial hypertension Mayo Clin Proc 69:169, 1994 RAICHLE ME, GRUBB RL, PHELPS ME, et al: Cerebral hemodynamics and metabolism in pseudotumor cerebri Ann Neurol 4:104, 1978 ROPPER AH (ed): Neurological and Neurosurgical Intensive Care, 4th ed Baltimore, Lippincott Williams & Wilkins, 2004 ROPPER AH, MARMAROU A: Mechanism of pseudotumor in GuillainBarre syndrome Arch Neurol 41:259, 1984 ROSMAN NP, SHANDS KN: Hydrocephalus caused by increased intracranial venous pressure: A clinicopathological study Ann Neurol 3:445, 1978 ROSNER MJ, BECKER DP: Origin and evolution of plateau waves J Neurosurg 60:312, 1984 RUSSELL DS: Observations on the Pathology of Hydrocephalus London, His Majesty s Stationery Of ce, 1949 SAFA-TISSERONT V, THROMANN F, MALASSINE P, et al: Anesthesiology 95:2, 2001 SAHS A, JOYNT RJ: Brain swelling of unknown cause Neurology 6:791, 1956 SCHIEVINK WI, MEYER FB, ATKINSON JL, MOKRI B: Spontaneous spinal cerebrospinal uid leaks and intracranial hypotension J Neurosurg 84: 598, 1996 SECKL J, LIGHTMAN S: Cerebrospinal uid neurohypophysial peptides in benign intracranial hypertension J Neurol Neurosurg Psychiatry 51: 1538, 1988 SHINNAR S, GAMMON K, BERGMAN EW JR, et al: Management of hydrocephalus in infancy: Use of acetazolamide and furosemide to avoid cerebrospinal uid shunts J Pediatr 107:31, 1985 SILVERBERG GD, LEVINTHAL E, SULLIVAN EV, et al: Assessment of low- ow CSF drainage as a treatment for AD: Results of a randomized pilot study Neurology 59:1139, 2002 SUGERMAN HJ, DEMARIA EJ, SISMANINS A: Gastric surgery for pseudotumor cerebri associated with obesity Ann Surg 229:634, 1999 SUGERMAN HJ, FELTON WL, SALVANT JB, et al: Effects of surgically induced weight loss on idiopathic intracranial hypertension in morbid obesity Neurology 45:1655, 1995 SYMONDS CP: Otitic hydrocephalus Brain 54:55, 1931 TRIPATHI BS, TRIPATHI RC: Vacuolar transcellular channels as a drainage pathway for CSF J Physiol (Lond) 239:195, 1974 VAN CREVEL H: Papilledema, CSF pressure, and CSF ow in cerebral tumours J Neurol Neurosurg Psychiatry 42:493, 1979 WALCHENBACH R, GEIGER E, THOMEER RJ, et al: The value of temporary external lumbar CSF drainage in predicting the outcome of shunting on normal pressure hydrocephalus J Neurol Neurosurg Psychiatr 72:503, 2002 WALKER RWH: Idiopathic intracranial hypertension: Any light on the mechanism of raised pressure J Neurol Neurosurg Psychiatry 71:1, 2001 WALL M, GEORGE D: Visual loss in pseudotumor cerebri Arch Neurol 44:170, 1987 WEED LH: Certain anatomical and physiological aspects of the meninges and cerebrospinal uid Brain 58:383, 1935.

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these library items You can realign the templates to different roles, ignore the role assignment, keep all role assignments, and other approaches We normally want to see that everything is positioned as it was in the older version, so the second radio button, Keep All Role Assignments, is normally what you will see selected I have not come across any issues with this step in the process and it has been fairly straightforward each time Even if you choose to migrate all items, you shouldn t run into any errors or concerns

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Speaking generally, tumors of the central nervous system (CNS) constitute a bleak but vitally important chapter of neurologic medicine Their importance derives from the facts that they occur in great variety; produce numerous neurologic symptoms because of their size, location, and invasive qualities; usually destroy the tissues in which they are situated and displace those around them; are a frequent cause of increased intracranial pressure; and, most of all, are often lethal Slowly this dismal state of affairs is changing, as a result of advances in anesthesiology, stereotactic and microneurosurgical techniques, radiation therapy, and the use of chemotherapeutic agents For clinicians, it should be a matter of general knowledge that: 1 Many types of tumor, both primary and secondary, occur in the cranial cavity and spinal canal Certain ones are much more frequent than others and are prone to occur in particular age groups Some tumors such as craniopharyngioma, meningioma, and schwannoma have a disposition to grow consistently in particular parts of the cranial cavity, thereby producing highly characteristic neurologic syndromes The presence of certain diseases such as AIDS, inherited disorders such as neuro bromatosis, or some systemic cancers predisposes to the development of tumors of the nervous system The growth rates and invasiveness of tumors vary; some, like the glioblastoma, are highly malignant, invasive, and rapidly progressive and others, like the meningioma, are benign, slowly progressive, and compressive These pathologic peculiarities are important, for they have valuable clinical implications, frequently providing the explanation of slowly or rapidly evolving clinical states and determining a good or poor prognosis Systemic neoplasms, by poorly understood mechanisms, may have remote effects on the nervous system, quite apart from those due to their compressive, in ltrative, or metastatic actions Moreover, these remote effects, referred to as paraneoplastic, may constitute the initial or only clinical manifestation of the underlying neoplasm Metastatic neoplasms are a far more common cause than are primary tumors of brain and spinal cord, and certain cancers display this tendency more than others.

Incidence of CNS Tumors and Their Types Currently, in each year there are an estimated 540,000 deaths from cancer in the United States Of these, the number of patients who died of primary tumors of the brain seems comparatively small (about 18,000, half of them malignant gliomas), but in roughly another 130,000 patients the brain is affected at the time of death by metastases Thus, in approximately 25 percent of all the patients with cancer, the brain and its coverings are involved by neoplasm at some time in the 546

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