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Listeria in only 40 percent of cases (blood cultures were even more often normal) Consistent with our experience, the early CT scan was often normal; MRI, however, has revealed abnormal signals in the parenchyma of the brainstem The monocytosis, which gives the organism its name, refers to the reaction in the peripheral blood in rabbits and has not been prominent in the blood or CSF of our cases One of the patients described by Lechtenberg and coworkers had a proven brain abscess; other patients have had multiple small abscesses (Uldry et al) Judging from the clinical signs in some cases, the infection appears to affect both the brainstem parenchyma and the extra-axial portion of cranial nerves Treatment The treatment is ampicillin (1 g intravenously every 4 h) in combination with tobramycin (5 mg/kg intravenously in three divided doses daily) If the condition of the host is compromised, the outcome is often fatal; but most of our patients without serious medical disease have made a full and prompt recovery with treatment Legionella This potentially fatal respiratory disease caused by the gram-negative bacillus Legionella pneumophila, rst came to medical notice in July 1976, when a large number of members of the American Legion fell ill at their annual convention in Philadelphia The fatality rate was high In addition to the obvious pulmonary infection, manifestations referable to the CNS and other organs were observed regularly Lees and Tyrrell described patients with severe and diffuse cerebral involvement, and Baker et al and Shetty et al described others with cerebellar and brainstem syndromes The clinical details have varied One constellation consisted of headache, obtundation, acute confusion or delirium with high fever, and evidence of pulmonary distress; another took the form of tremor, nystagmus, cerebellar ataxia, extraocular muscle and gaze palsies, and dysarthria Other neurologic abnormalities have been observed, such as inappropriate ADH secretion, or a syndrome of more diffuse encephalomyelitis or transverse myelitis, similar to that observed with Mycoplasma infections The CSF is usually normal and CT scans of the brain are negative, a circumstance that makes diagnosis dif cult The neuropathologic abnormalities have not been studied Suspicion of the disease, based on suspected exposure or on the presence of an atypical pneumonia, should prompt tests for serum antibodies to the bacillus, which rise to high levels in a week to 10 days In most patients the signs of CNS disorder resolve rapidly and completely, although residual impairment of memory and a cerebellar ataxia have been recorded To date, the Legionella bacillus has not been isolated from the brain or spinal uid Treatment Treatment in adults has consisted of erythromycin, 05 to 10 g intravenously q 6 h for a 3-week period The combination of the erythromycin analogue azithromycin and cipro oxacin (a quinolone) is believed to be more potent Cat-Scratch Encephalitis Reports of approximately 100 cases of encephalitis from cat-scratch disease have appeared in the medical literature The causative organism is a gram-negative bacillus now called Rochalimaea henselae (formerly Bartonella henselae) The illness begins as unilateral axillary or cervical adenopathy occurring after a seemingly innocuous scratch (rarely a bite) from an infected cat The cases with which we are familiar began with an encephalopathy and high fever (higher temperature than with most of the other organisms that are capable of causing a bacterial encephalitis), followed by seizures or status epilepticus The organism has also been implicated in causing a focal cerebral vasculitis in. .net data matrix barcode Data Matrix VB . NET Control - Data Matrix barcode generator with ...
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