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occasion an organism is cultured If the patient is stuporous or comatose, there is a risk in performing a lumbar puncture, and one should proceed rst with other diagnostic procedures By CT scanning one can see the ear or sinus lesions or bone erosion The meninges around the empyema enhance and the collection of pus can be visualized more dependably with MRI Empyema that follows meningitis tends to localize on the undersurface of the temporal lobe and may require coronal views in order to be well visualized Several conditions must be distinguished clinically from subdural empyema a treated subacute bacterial meningitis, cerebral thrombophlebitis, brain abscess (see further on), herpes simplex encephalitis (page 638), acute necrotizing hemorrhagic leukoencephalitis (page 792), and septic embolism due to bacterial endocarditis (see further on in this chapter) Treatment Most subdural empyemas, by the time they are recognized clinically, require immediate drainage through multiple enlarged frontal burr holes or through a craniotomy in cases with an interhemispheric, subtemporal, or posterior fossa location The surgical procedure should be coupled with appropriate antibiotic therapy, which consists in most cases of the intravenous administration of 20 to 24 million units of penicillin per day plus a thirdgeneration cephalosporin and metronidazole Bacteriologic ndings or an unusual presumed source may dictate a change to different drugs, particularly to later-generation cephalosporins Without such massive antimicrobial therapy and surgery, most patients will die, usually within 7 to 14 days On the other hand, patients who are treated promptly may make a surprisingly good recovery, including full or partial resolution of their focal neurologic de cits As with certain small brain abscesses, small subdural collections of pus that are recognized by CT scanning or MRI before stupor and coma have supervened may respond to treatment with large doses of antibiotics alone The resolution (or lack thereof) of the empyema can be readily followed by repeated imaging of the brain (Leys et al). .net pdf 417 PDF - 417 C# Control - PDF - 417 barcode generator with free C# ...
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