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With this approach, items assessing a basic trait would form a genetically homogeneous unit as opposed to a factorially homogeneous unit Items could then be selected according to their correlation with the underlying genetic dimension Thus items forming a scale would share the same general and speci c genetic etiology With this approach, the goal would be to use behavioral genetic techniques to bring about de nitions of the phenotype that correspond to what Farone, Tsuang, and Tsuang (1999) refer to as genetically crisp categories (p 114) An example of this approach is provided by a study of the genetic structure of the Eysenck Personality Questionnaire (Heath, Eaves, & Martin, 1989) This instrument has three broad scales composed of 21 to 25 items that assess Neuroticism, Extraversion, and Psychoticism Heath and colleagues extracted a common genetic and environmental factor for Neuroticism and Extraversion, indicating that these items are etiologically homogeneous.

In contrast, little evidence was found for a common genetic factor for the Psychoticism items Subsequent analyses showed that the items formed into two distinct genetic factors: paranoid attitudes and hostile behavior The results of such a systematic evaluation of item etiology could be used to form etiologically homogeneous scales This approach could be used either to develop new scales or modify existing scales so that they resemble the underlying genetic architecture more closely This could be achieved by applying differential weights that index the in uence of speci c genetic and environmental in uences on different traits In this way, questions about the phenotypic structure of personality are addressed, and scales could be constructed so that they do not re ect competing genetic and environmental in uences The estimation of genetic and environmental factor scores is a relatively new and active area of research Sham et al.

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, Emmanual, J, Marquis, JC, Langer, R (1994a) Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds J Biomed Mater Res 28: 891 899 Freed, LE, Marquis, JC, Vunjak-Novakovic, G, Emmanual, J, Langer, R (1994b) Composition of cell-polymer cartilage implants Biotechnol Bioeng 43: 605 614 Freed, LE, Vunjak-Novakovic, G, Biron, R, Eagles, D, Lesnoy, D, Barlow, S, Langer, R (1994c) Biodegradable polymer scaffolds for tissue engineering Bio/Technology 12: 689 693 Freed, LE, and Vunjak-Novakovic, G (1995) Cultivation of cell-polymer constructs in simulated microgravity Biotechnol Bioeng 46: 306 313 Freed, LE, Langer, R, Martin, I, Pellis, N, Vunjak-Novakovic, G (1997) Tissue engineering of cartilage in space Proc Natl Acad Sci USA 94: 13885 13890 Freed, LE, Hollander, AP, Martin, I, Barry, J.

(2001) recently described a method that permits these genetic.

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If you are already writing HTML pages, you may need to break your bad habits. You probably already think in terms of getting the browser to make your page look the right way. And you use HTML to make it do this. If you are really underhanded, you may even use goofy conventions such as 1-pixel-wide clear image files (usually GIFs) and stretch them to indent your paragraphs. With HTML 4 you needn t out-maneuver the browser. Browsers that support the HTML 4 standards display your pages as you define them no more of that arrogant printer stuff! And fortunately, with HTML 4, you can define the way you want your pages to look outside of the content, so your HTML won t be all cluttered with tags.

R, Langer, R, Vunjak-Novakovic, G (1998) Chondrogenesis in a cell-polymer-bioreactor system Exp Cell Res 240: 58 65 Freed, LE, Martin, I, Vunjak-Novakovic, G (1999) Frontiers in tissue engineering: in vitro modulation of chondrogenesis Clin Orthop Rel Res 367S: S46 S58 Freed, LE, and Vunjak-Novakovic, G (2000a) Tissue engineering bioreactors In Lanza, RP, Langer, R, Vacanti, J, eds, Principles of Tissue Engineering San Diego, Academic Press, pp 143 156 Freed, LE, and Vunjak-Novakovic, G (2000b) Tissue engineering of cartilage In Bronzino, JD, ed, The Biomedical Engineering Handbook Boca Raton, CRC Press, pp 124 126 Gao, J, Niklason, L, Langer, R (1998) Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells J Biomed Mater Res 42: 417 424 Gooch, KJ, Blunk, T, Courter, DL.

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